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KMID : 1123920080220030585
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 3 p.585 ~ p.592
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Inhibitory Effect of Allergic Reaction by Gunggwihyangso-San
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Kwon Ki-Won
Shin Sang-Woo
Park Jong-Hyun
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Abstract
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The present study was conducted to investigate the anti-allergic activity of Gunggwihyangso-San(GHS). We investigated the anti-allergic effects of GHS in RBL-2H3 basophilic leukemia cells by compound 48/80, a mast cell degranulator and compound 48/80 induced anaphylactic shock in mice. Gunggwihyangso-San significantly inhibited -hexosaminidase and histamine release from compound 48/80 stimulated RBL-2H3 cells. In addition, GHS effectively inhibited anaphylactic shock in mice by 50% at a dose 80 mg/mouse versus PBS treated control after the I.p injection(8 mg/kg) of compound 48/80. The in vitro anti-inflammatory activities of GHS in LPS-stimulated RAW 264.7 cells were investigated. GHS inhibited NO production in LPS-stimulated RAW 264.7 cells and effectively dowregulated the expression of iNOS mRNA and iNOS protein expression in LPS-stimulated RAW 264.7 cells. These result provide evidences that GHS may be beneficial in the treatment of allergic inflammtory disease.
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KEYWORD
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Gunggwihyangso-San, compound48/80β-hexosaminidase, histamine release, nitric oxide
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